Potential Gene Involved in Multiple Sclerosis
Multiple sclerosis (MS) and leukodystrophies (such as the disease featured in the movie Lorenzo’s Oil) are diseases in which myelin, the fatty layer coating nerves in the brain and spinal cord, is destroyed. According to The Myelin Project, over two million people worldwide are affected by demyelinating diseases.
Researchers at the National University of Singapore have identified a gene in rats that appears to affect oligodendrocytes, cells in the central nervous system that produce myelin. The juxtanodin gene changed oligodendrocyte motility, differentiation, or myelin-axon signaling. (PNAS, July 28, 2005)
One of the ways scientists hope to remyelinate nerve cells is to transplate myelin-forming cells such as stem cells. Another way is by drugs such as a progesterone derivative and a combined statin and interferon-beta therapy for use in treating MS. Identifying the specific genes responsible for making myelin will make it possible to develop more effective gene-targeted pharmaceuticals.
The Straits Times, July 27, 2005
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POSTED IN: General Genetics and Health
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2 opinions for Potential Gene Involved in Multiple Sclerosis
Qadira
Aug 1, 2005 at 8:27 pm
That went in one ear and out the other. Would such a treatment stop the progression of MS, or is this saying there’s a possible hope to actually reverse the ravaging effects the disease has? Either way is awesome, and I hope they figure it out in time for my aunt to take advantage of the therapy.
Lei
Aug 1, 2005 at 11:28 pm
Sorry, Qadira. Not my finest piece of writing, I’m afraid. :P The basic gist of this finding is that a gene for myelination has been found. Being able to control it could mean much better and direct treatment than stem cells or treatments targeting the immune system.
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