RPS3A Gene Associated with Alzheimer’s Disease
The RPS3A gene on chromsome 10 has been found to increase the risk of late-onset Alzheimer’s disease. Celera Diagnostics studied more than 1,700 Alzheimer’s cases and more than 1,700 age-matched controls. Previously, they identified associations between Alzheimer’s disease and novel genetic variants in the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene and also in the amyloid precursor protein binding protein B2 (APPB2).
A company with the resources of Celera has a good chance of thoroughly screening millions of single nucleotide polymorphisms (SNPs) that may affect gene function.
Celera Diagnostics compares genotype and/or gene expression profiles in samples from healthy and affected individuals to associate genetic and genomic markers with disease. To cost-effectively complete genome-wide scans, Celera Diagnostics operates an industrial-scale facility and utilizes proprietary data and know-how, including novel functional SNPs discovered by the Applera Genomics Initiative. Functional SNPs are those most likely to affect the function, amount or stability of proteins. Celera Diagnostics is currently conducting large-scale disease association studies for multiple common, complex diseases, including four forms of cardiovascular disease, breast cancer, rheumatoid arthritis, psoriasis, Alzheimer’s disease, and liver disease. The pharmacogenomic studies include statin therapy and interferon responsiveness for HCV infection.
It’s good to see that they’re sharing the knowledge via peer-reviewed journals, such as the American Journal of Human Genetics.
By the way, I have a daily visitor from Celera and I’d like to say hello. Would you mind e-mailing me at hsienlei@b5media.com? Thanks.
Business Wire, December 6, 2005
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POSTED IN: Genetics of Disease
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