Saturday Genetics Quiz #24: Naming Genes
This week’s genetics questions are about human gene nomenclature:
1. Can gene names include symbols or punctuation?
2. What letter is excluded from gene names?
3. A number of genes highlighted in Genetics and Health start with “SLC.” What does SLC stand for?
4. Are gene names written using British or American spelling?
5. Who’s in charge of approving a gene name and symbol?
Answers:
1. No. Gene names can only contain Latin letters and Arabic numerals.
2. Gene names should not contain “G” for gene.
3. SLC stands for “solute carrier superfamily”.
4. Gene names use American spelling. (Don’t ask me why. I’m just the messenger.)
5. The HUGO Gene Nomenclature Committee is a non-profit organization made-up of post-docs and bioinformaticians.
NB: This rule made me laugh.
6.1 Antisense
A gene of unknown function, encoded at the same genomic locus (with overlapping exons) as another gene should have its own symbol. If the new gene regulates the first gene it may be assigned the symbol of the first gene with the suffix AS for antisense e.g. IGF2AS “insulin-like growth factor 2, antisense”. The gene symbol should not be written backwards.
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