Genetics and Health

6 opinions for Genes for Nicotine Metabolism

• Jay
  Apr 25, 2006 at 5:53 pm

  All the more reason to not smoke around children. Is there a way to predetermine whether or not your children have these genes that make them more exposed to carcinogens?

• Hsien Hsien Lei, PhD
  Apr 26, 2006 at 4:22 pm

  Jay: There aren’t any commercially available tests at this point (as far as I’m aware of) that would test children for these genetic variants. And if there were, the prices wouldn’t be too cheap either. The easiest way is just to avoid smoking as one of the most common carcinogenic agents out there!

• Hsien Hsien Lei, PhD
  Apr 26, 2006 at 4:33 pm

  Oops, I was wrong. Cellf aka Sciona offers commercial tests for GSTM1 and GSTT1.

  If you got a hundred dollars or so to spare, you could find out your genotype, but I’d probably be able to find better uses for those dollars….

• Hsien Hsien Lei, PhD
  Apr 26, 2006 at 4:41 pm

  Sorry, upon further research, I also see there are clinical services available that would test for these genes, e.g., DxS Genotyping.

• Dirk
  Oct 4, 2007 at 5:47 pm

  hsien thanks for the info

• Megan
  Oct 30, 2007 at 6:14 pm

  I was born with a cleft palate. My parents both smoked. I am 38 years old, live in Los Angeles, and have recently been diagnosed with Fibromyalgia. I am curious if you know of any studies on the GSTT1 gene and Fibromyalgia. I definitely felt worse this past week with the fires and ash in the air? It would make sense that if this gene didn’t clear smoke in vitro, that it might still affect me as an adult? Thanks.

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