Genetics of Orthostatic Intolerance
or Ode to Greg Page Wiggle
Over at my other blog, Play Library, we’re having a Greg Page Wiggle Tribute Day in honor of the yellow Wiggle who officially announced his retirement because he has a chronic condition called orthostatic intolerance (OI). News reports have mentioned that the condition is partly genetic so I thought I’d look it up (of course!).
According to OMIM, a mutation in the norepinephrine transporter gene (SLC6A2) has been linked to orthostatic intolerance. The syndrome involves the body’s inability to transmit the proper signals to maintain homeostasis of the cardiovascular system. Other names for the syndrome are:
- Soldiers Heart
- Neurocirculatory Asthenia
- Mitral Valve Prolapse Syndrome
There also appears to be a strong correlation between OI and chronic fatigue syndrome. More information at the CFIDS Association of America.
Technorati Tags: greg page, greg wiggle, yellow wiggle, the wiggles, genetics, genes, orthostatic intolerance, dna, slc6a2, norepinephrine transporter gene, diseases, illness, health
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POSTED IN: Genetics of Disease
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2 opinions for Genetics of Orthostatic Intolerance
Tammy Ray
Dec 2, 2006 at 6:36 pm
My sister and I suffer with these conditions and to be honest the best treatment of all is friends and family at your side! Good luck, My kids and I will miss you!
Hsien Hsien Lei, PhD
Dec 4, 2006 at 9:52 am
Tammy: Thanks for your comment. I’m sorry to hear you and your sister both have OI. Wishing you all the best as well!!
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